description
ERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. 1995, Sepp-Lorenzino et al. 1996), which, again, results in SOS1-mediated guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinases (Janes et al. 1994, Sepp-Lorenzino et al. 1996)

external resources
NCBI:1269491
REACTOME:R-HSA-1963640

genes
BTC , HBEGF , EGF , EGFR , ERBB2 , ERBB4 , EREG , GRB2 , NRG1 , HRAS , KRAS , NRAS , SOS1 , NRG2 , NRG3 , NRG4 ,