description
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases

external resources
NCBI:83122
KEGG:hsa05322
PUBMED:12835292
PUBMED:12965173
PUBMED:16932712
PUBMED:10025913
PUBMED:15972354
PUBMED:17943287
PUBMED:10430616
PUBMED:18305268
PUBMED:15380523
PUBMED:8048228
PUBMED:15459673

genes
ACTN4 , ACTN1 , C1QA , C1QB , C1QC , C1R , C1S , C2 , C3 , C4A , C4B , C5 , C6 , C7 , C8A , C8B , C8G , C9 , CD28 , CD80 , CD86 , CD40 , CD40LG , CTSG , ELANE , FCGR1A , FCGR2A , FCGR3A , FCGR3B , GRIN2A , GRIN2B , HIST1H2AE , HIST1H2AD , H2AFX , H2AFZ , HIST1H2BD , HIST1H2BB , H3F3A , H3F3B , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , IFNG , IL10 , SNRPB , SNRPD1 , SNRPD3 , TRIM21 , TROVE2 , SSB , TNF , HIST3H3 , HIST1H4I , HIST1H2AI , HIST1H2AK , HIST1H2AJ , HIST1H2AL , HIST1H2AC , HIST1H2AB , HIST1H2AM , HIST2H2AA3 , HIST2H2AC , HIST1H2BG , HIST1H2BL , HIST1H2BN , HIST1H2BM , HIST1H2BF , HIST1H2BE , HIST1H2BH , HIST1H2BI , HIST1H2BC , HIST1H2BO , HIST2H2BE , HIST1H3A , HIST1H3D , HIST1H3C , HIST1H3E , HIST1H3I , HIST1H3G , HIST1H3J , HIST1H3H , HIST1H3B , HIST1H4A , HIST1H4D , HIST1H4F , HIST1H4K , HIST1H4J , HIST1H4C , HIST1H4H , HIST1H4B , HIST1H4E , HIST1H4L , HIST1H4G , HIST2H4A , HIST1H3F , HIST1H2AG , HIST1H2BJ , H2AFY , H2AFY2 , H2AFJ , H2AFB3 , HIST1H2AH , HIST1H2BK , HIST3H2A , H2AFV , HIST4H4 , HIST2H3C , HIST3H2BB , H2BFWT , HIST1H2AA , HIST1H2BA , H2BFM , HIST2H2AB , HIST2H3A , H3F3C , HIST2H2BF , H2AFB2 , H2AFB1 , HIST2H4B , HIST2H3D , HIST2H2AA4 ,