description
In the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcription factors (Chen et al. 2002, Varelas et al. 2008, Stroschein et al. 1999, Wotton et al. 1999). In addition, the activity of SMAD2/3:SMAD4 complex can be inhibited by nuclear protein phosphatases and ubiquitin ligases (Lin et al. 2006, Dupont et al. 2009)

external resources
NCBI:1269527
REACTOME:R-HSA-2173793
PUBMED:12150994
PUBMED:16751101
PUBMED:10199400
PUBMED:18568018
PUBMED:19135894
PUBMED:10531062

genes
PARP1 , CCNC , CCNT1 , CCNT2 , CDK8 , CDK9 , CDKN2B , E2F4 , E2F5 , HDAC1 , JUNB , SMAD2 , SMAD3 , SMAD4 , SMAD7 , MEN1 , MYC , SERPINE1 , PPM1A , RBL1 , RPS27A , SKI , SKIL , SP1 , TFDP1 , TFDP2 , TGIF1 , UBA52 , UBB , UBC , UBE2D1 , UBE2D3 , USP9X , CCNK , NCOR1 , NCOR2 , SNW1 , NEDD4L , ATP1B4 , WWTR1 , TRIM33 , RNF111 , TGIF2 , SMURF2 , MIR2861 , MIR3960 ,