description
NOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a membrane bound ligand expressed in trans on the surface of a neighboring cell. In trans, ligand binding triggers proteolytic cleavage of NOTCH1 and results in release of the NOTCH1 intracellular domain, NICD1, into the cytosol.NICD1 translocates to the nucleus where it associates with RBPJ (also known as CSL or CBF) and mastermind-like (MAML) proteins (MAML1, MAML2, MAML3 or MAMLD1) to form NOTCH1 coactivator complex. NOTCH1 coactivator complex activates transcription of genes that possess RBPJ binding sites in their promoters

external resources
NCBI:1269535
REACTOME:R-HSA-1980143
PUBMED:20972443
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genes
ADAM10 , JAG1 , ARRB1 , ARRB2 , CCNC , CDK8 , CNTN1 , CREBBP , DTX1 , EP300 , KAT2A , HDAC1 , HDAC2 , HIF1A , HES1 , RBPJ , JAG2 , MYC , NOTCH1 , PSEN2 , RPS27A , SKP1 , ADAM17 , TBL1X , TLE1 , TLE2 , TLE3 , TLE4 , UBA52 , UBB , UBC , CUL1 , NUMB , DLK1 , HDAC3 , KAT2B , NEURL1 , NCOR1 , NCOR2 , HDAC9 , HDAC4 , MAML1 , RBX1 , HDAC6 , HDAC5 , MAMLD1 , SNW1 , DTX4 , NCSTN , HEY1 , HEY2 , HEYL , DLL1 , APH1A , HDAC7 , NEURL1B , DLL4 , FBXW7 , MAML3 , PSENEN , HDAC8 , MIB1 , TBL1XR1 , HDAC11 , APH1B , ITCH , HDAC10 , MAML2 , DNER , DTX2 , MIB2 , HES5 , MIR1281 ,