description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production

external resources
NCBI:99051
KEGG:hsa04062
PUBMED:17371236
PUBMED:19159344
PUBMED:17169327
PUBMED:10852130
PUBMED:9765254
PUBMED:15771581
PUBMED:14607270
PUBMED:18662984
PUBMED:12495636
PUBMED:15803148
PUBMED:15046611
PUBMED:12069927
PUBMED:18711432
PUBMED:17675482
PUBMED:16144840
PUBMED:17496928
PUBMED:17537990
PUBMED:11872087
PUBMED:12051620
PUBMED:14625285
PUBMED:8576262
PUBMED:11244042

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GRK2 , GRK3 , AKT1 , AKT2 , RHOA , ARRB1 , ARRB2 , CXCR5 , BRAF , CDC42 , CHUK , CCR1 , CCR3 , CCR4 , CCR5 , CCR6 , CCR7 , CCR8 , CRK , CRKL , CX3CR1 , DOCK2 , PTK2B , FGR , FOXO3 , GNAI1 , GNAI2 , GNAI3 , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , CCR10 , XCR1 , CXCR3 , GRK4 , GRK5 , GRK6 , GRB2 , CXCL1 , CXCL2 , CXCL3 , GSK3A , GSK3B , HCK , HRAS , IKBKB , CXCL8 , CXCR1 , CXCR2 , CXCL10 , ITK , JAK2 , JAK3 , KRAS , LYN , CXCL9 , NFKB1 , NFKBIA , NFKBIB , NRAS , PAK1 , PF4 , PF4V1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCB2 , PLCB3 , PLCB4 , PPBP , PRKACA , PRKACB , PRKACG , PRKCB , PRKCD , PRKCZ , MAPK1 , MAPK3 , MAP2K1 , PTK2 , PXN , RAC1 , RAC2 , RAF1 , RAP1A , RAP1B , RELA , GRK1 , ROCK1 , CCL1 , CCL2 , CCL3 , CCL3L1 , CCL4 , CCL5 , CCL7 , CCL8 , CCL11 , CCL13 , CCL14 , CCL15 , CCL16 , CCL17 , CCL18 , CCL19 , CCL20 , CCL21 , CCL22 , CCL23 , CCL24 , CCL25 , CXCL6 , CXCL11 , CXCL5 , CX3CL1 , CXCL12 , SHC1 , SOS1 , SOS2 , SRC , STAT1 , STAT2 , STAT3 , STAT5B , TIAM1 , VAV1 , VAV2 , WAS , CXCR4 , PIK3R3 , IKBKG , WASL , ROCK2 , CCL4L2 , BCAR1 , ELMO1 , AKT3 , RASGRP2 , CCL26 , VAV3 , CXCL13 , CXCR6 , GNB5 , CCR9 , CCL27 , PLCB1 , SHC2 , GNG13 , SHC3 , GNG2 , GNG12 , PARD3 , CCL28 , PREX1 , CXCL16 , GNB4 , GNG8 , GRK7 , ADCY4 , CCL4L1 , SHC4 , CCL3L3 , NCF1 , CCR2 ,