description
The Lysophospholipid receptor (LPLR) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans there are eight LPL receptors, each encoded by a separate gene (these genes also sometimes referred to as "Edg" or endothelial differentiation gene). The ligands for LPLRs are the lysophospholipid extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The primary effects are inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventing apoptosis and increasing cell proliferation (Contos JJ et al, 2000; An S et al, 1998; Fukushima N and Chun J, 2001)

external resources
NCBI:1269567
REACTOME:R-HSA-419408
PUBMED:9893266
PUBMED:11093753
PUBMED:11324705

genes
S1PR1 , LPAR1 , S1PR3 , S1PR4 , LPAR2 , S1PR2 , PLPPR4 , LPAR3 , S1PR5 , PLPPR1 , LPAR5 , PLPPR2 , PLPPR3 , PLPPR5 ,