description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy

external resources
NCBI:99052
KEGG:hsa04142
PUBMED:2943218
PUBMED:12628346
PUBMED:1883197
PUBMED:18635948
PUBMED:15987739

genes
ABCA2 , ACP2 , ACP5 , AP1B1 , AP1G1 , AGA , ARSA , ARSB , ASAH1 , ATP6V0C , ATP6V0B , ATP6V0A1 , ATP6AP1 , SCARB2 , CD63 , CD68 , CTSC , AP1S1 , AP3S1 , TPP1 , CLN3 , CLN5 , CLTA , CLTB , CLTC , CTNS , CTSB , CTSD , CTSE , CTSG , CTSH , CTSK , CTSL , CTSV , CTSO , CTSS , CTSW , CTSZ , DNASE2 , FUCA1 , GAA , GALC , GALNS , GBA , GLA , GLB1 , GM2A , GNS , GUSB , HEXA , HEXB , HYAL1 , IDS , IDUA , IGF2R , LAMP1 , LAMP2 , LIPA , M6PR , MAN2B1 , MANBA , NAGA , NAGLU , NEU1 , NPC1 , SLC11A2 , CTSA , PPT1 , LGMN , PSAP , SORT1 , SGSH , SLC11A1 , SMPD1 , LAPTM5 , AP3B2 , CLTCL1 , AP3B1 , CTSF , CD164 , AP1S2 , AP1G2 , AP1M1 , AP3D1 , ATP6V0D1 , AP4M1 , PPT2 , NAPSA , LITAF , ENTPD4 , LAPTM4A , AP1M2 , AP3S2 , TCIRG1 , NPC2 , AP4B1 , AP3M2 , AP4S1 , ARSG , GGA2 , GGA3 , AP4E1 , ABCB9 , ATP6V0A2 , PLA2G15 , GGA1 , SLC17A5 , AP3M1 , LAMP3 , ATP6V0A4 , NAGPA , ATP6V1H , LAPTM4B , MCOLN1 , DNASE2B , GNPTAB , GNPTG , AP1S3 , HGSNAT , ATP6V0D2 , MFSD8 , SUMF1 , PSAPL1 ,