description
The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated

external resources
NCBI:1269575
REACTOME:R-HSA-418555
PUBMED:12036966

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ADCYAP1 , ADCYAP1R1 , ADM , ADORA2A , ADORA2B , ADRB1 , ADRB2 , ADRB3 , GRK2 , GRK3 , ARRB1 , ARRB2 , AVP , AVPR2 , CALCA , CALCB , CALCR , CGA , CRH , CRHR1 , CRHR2 , DRD1 , DRD5 , FSHB , FSHR , GCG , GCGR , GHRH , GHRHR , GIP , GIPR , GLP1R , GNAI1 , GNAI2 , GNAI3 , GNAS , GNAZ , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , GPR15 , GPR20 , GPR25 , GPR27 , GPR32 , GRK5 , GRK6 , HRH2 , HTR4 , HTR6 , HTR7 , IAPP , INSL3 , LHB , LHCGR , MC1R , MC2R , MC3R , MC4R , MC5R , P2RY11 , PDE1A , PDE2A , PDE3A , PDE3B , PDE4A , PDE4B , PDE4C , PDE4D , PDE7A , PDE8A , PDE1B , POMC , PTGDR , PTGER2 , PTGER4 , PTGIR , PTH , PTHLH , PTH1R , PTH2R , RLN2 , SCT , SCTR , TSHB , TSHR , VIP , VIPR1 , VIPR2 , PDE8B , TAAR5 , TAAR2 , TAAR3P , GLP2R , CALCRL , RAMP2 , RAMP1 , RAMP3 , GNB5 , PDE10A , GPR83 , GPR176 , GPR45 , PDE7B , PDE11A , GNG13 , GPR84 , GNG2 , GNG12 , GNB4 , RXFP1 , ADM2 , TAAR8 , GNG8 , PTH2 , RLN3 , RXFP2 , GPHB5 , TAAR9 , TAAR1 , GPBAR1 , GPHA2 , ADCY4 , GPR150 , TAAR6 , GNAT3 , NPSR1 , MIR197 , NPS , LOC729966 ,