description
The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases

external resources
NCBI:1269576
REACTOME:R-HSA-418594
PUBMED:3113327
PUBMED:9278091

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ADORA1 , ADORA3 , ADRA2A , ADRA2B , ADRA2C , AGT , AGTR2 , APLNR , ANXA1 , APP , OPN1SW , BDKRB1 , BDKRB2 , CXCR5 , C3 , C3AR1 , C5 , C5AR1 , CASR , CHRM2 , CHRM4 , CCR1 , CCR3 , CCR4 , CCR5 , CCR6 , CCR7 , CCR8 , CNR1 , CNR2 , CORT , DRD2 , DRD3 , DRD4 , S1PR1 , LPAR1 , S1PR3 , FPR1 , FPR2 , FPR3 , GABBR1 , GALR1 , OPN1MW , GNAI1 , GNAI2 , GNAI3 , GNAS , GNAT1 , GNAT2 , GNAZ , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , CCR10 , NPBWR1 , NPBWR2 , CXCR3 , GPR17 , GPR18 , MCHR1 , GPER1 , GRM2 , GRM3 , GRM4 , GRM6 , GRM7 , GRM8 , CXCL1 , CXCL2 , CXCL3 , HTR1A , HTR1B , HTR1D , HTR1E , HTR1F , HTR5A , CXCL8 , CXCR1 , CXCR2 , CXCL10 , KNG1 , CXCL9 , MTNR1A , MTNR1B , NPY , NPY1R , NPY2R , NPY5R , OPRD1 , OPRK1 , OPRL1 , OPRM1 , P2RY4 , PDYN , PENK , PF4 , PMCH , PNOC , POMC , PPBP , PPY , NPY4R , PYY , TAS2R38 , PTGER3 , OPN1LW , RGR , RGS1 , RGS4 , RGS7 , RGS10 , RGS12 , RGS13 , RGS16 , RHO , SAA1 , CCL5 , CCL16 , CCL19 , CCL20 , CCL21 , CCL23 , CCL25 , CXCL6 , CXCL11 , CXCL5 , CXCL12 , SST , SSTR1 , SSTR2 , SSTR3 , SSTR4 , SSTR5 , CXCR4 , GALR3 , RGS5 , RGS20 , S1PR4 , RGS11 , RGS9 , GALR2 , HCAR3 , APLN , LPAR2 , GPR55 , S1PR2 , GABBR2 , RGS6 , P2RY14 , INSL5 , RGS19 , NMUR1 , CXCL13 , RGS14 , CXCR6 , GNB5 , RRH , CCR9 , CCL27 , NMU , PTGDR2 , HRH3 , LPAR3 , OPN3 , GPSM1 , RGS22 , HCAR1 , OXGR1 , TAS2R3 , TAS2R4 , TAS2R16 , TAS2R1 , TAS2R9 , TAS2R8 , TAS2R7 , TAS2R13 , TAS2R10 , TAS2R14 , HEBP1 , GAL , RXFP3 , GNG13 , S1PR5 , P2RY13 , GNG2 , TAS2R5 , GNG12 , CCL28 , SUCNR1 , NMUR2 , ACKR3 , LPAR5 , CXCL16 , HRH4 , GNB4 , RGS18 , P2RY12 , MCHR2 , RGS8 , GNG8 , RLN3 , NMS , OXER1 , ADCY4 , OPN5 , NPB , TAS2R39 , TAS2R40 , TAS2R41 , TAS2R43 , TAS2R31 , TAS2R46 , TAS2R30 , TAS2R19 , TAS2R20 , TAS2R50 , NPW , TAS2R60 , HCAR2 , RXFP4 , GNAT3 , TAS2R42 , RGSL1 , MIR197 , RGS21 , CCR2 ,