description
The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha
external resources
NCBI:1269580
REACTOME:R-HSA-397795
PUBMED:18834311
genes
AKT1
,
AKT2
,
RHOA
,
CSF2
,
CSF2RA
,
CSF2RB
,
GNB1
,
GNB2
,
GNB3
,
GNG3
,
GNG4
,
GNG5
,
GNG7
,
GNG10
,
GNG11
,
GNGT1
,
GNGT2
,
GRB2
,
IL2
,
IL2RA
,
IL2RB
,
IL2RG
,
IL3
,
IL3RA
,
IL5
,
IL5RA
,
JAK1
,
JAK2
,
JAK3
,
PDPK1
,
PIK3CA
,
PIK3CB
,
PIK3CD
,
PIK3CG
,
PIK3R1
,
PIK3R2
,
PLCB2
,
PLCB3
,
SHC1
,
PIK3R3
,
GAB2
,
AKT3
,
GNB5
,
PLCB1
,
PIK3R5
,
GNG13
,
GNG2
,
GNG12
,
GNB4
,
GNG8
,
PIK3R6
,
