description
PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3
external resources
NCBI:1269581
REACTOME:R-HSA-392451
PUBMED:17916723
PUBMED:17041586
genes
AKT1
,
AKT2
,
RHOA
,
CSF2
,
CSF2RA
,
CSF2RB
,
GNB1
,
GNB2
,
GNB3
,
GNG3
,
GNG4
,
GNG5
,
GNG7
,
GNG10
,
GNG11
,
GNGT1
,
GNGT2
,
GRB2
,
IL2
,
IL2RA
,
IL2RB
,
IL2RG
,
IL3
,
IL3RA
,
IL5
,
IL5RA
,
JAK1
,
JAK2
,
JAK3
,
PDPK1
,
PIK3CA
,
PIK3CB
,
PIK3CD
,
PIK3CG
,
PIK3R1
,
PIK3R2
,
SHC1
,
PIK3R3
,
GAB2
,
AKT3
,
GNB5
,
PIK3R5
,
GNG13
,
GNG2
,
GNG12
,
GNB4
,
GNG8
,
PIK3R6
,
