description
Phospholipase C beta (PLCbeta) isoforms are activated by G-protein beta:gamma in the order PLCB3 > PLCB2 > PLCB1. Gbeta:gamma binds to the pleckstrin homology domain of PLC beta, increasing phospholipase activity and leading to increased hydrolysis of PIP2 to DAG and IP3

external resources
NCBI:1269582
REACTOME:R-HSA-418217
PUBMED:8383116

genes
GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , PLCB2 , PLCB3 , GNB5 , PLCB1 , GNG13 , GNG2 , GNG12 , GNB4 , GNG8 ,