description
Phospholipase C beta (PLCbeta) isoforms are activated by G-protein beta:gamma in the order PLCB3 > PLCB2 > PLCB1. Gbeta:gamma binds to the pleckstrin homology domain of PLC beta, increasing phospholipase activity and leading to increased hydrolysis of PIP2 to DAG and IP3
external resources
NCBI:1269582
REACTOME:R-HSA-418217
PUBMED:8383116
genes
GNB1
,
GNB2
,
GNB3
,
GNG3
,
GNG4
,
GNG5
,
GNG7
,
GNG10
,
GNG11
,
GNGT1
,
GNGT2
,
PLCB2
,
PLCB3
,
GNB5
,
PLCB1
,
GNG13
,
GNG2
,
GNG12
,
GNB4
,
GNG8
,
