description
The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions

external resources
NCBI:1269587
REACTOME:R-HSA-112043
PUBMED:9218123
PUBMED:16183910
PUBMED:1335363

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , GRK2 , CALM1 , CALM2 , CALM3 , CAMK4 , CREB1 , GNAI1 , GNAI2 , GNAI3 , GNAO1 , GNAT1 , GNAT2 , GNAZ , ITPR1 , ITPR2 , ITPR3 , PDE1A , PDE1C , PDE1B , PLA2G4A , PLCB2 , PLCB3 , PLCB4 , PRKACA , PRKACB , PRKACG , PRKAR1A , PRKAR1B , PRKAR2A , PRKAR2B , PRKCA , PRKCD , PRKCG , MAPK1 , AHCYL1 , PLCB1 , ADCY4 , GNAT3 , MIR197 ,