description
Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation DARPP-32 phosphorylation provides a mechanism for integrating information arriving at dopaminoceptive neurons, in multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at Thr34, converting DARPP-32 into a potent inhibitor of protein phosphatase-1 (PP-1). DARPP-32 is also phosphorylated at Thr75 by Cdk5, converting DARPP-32 into an inhibitor of PKA. Thus, DARPP-32 has the unique property of being a dual-function protein, acting either as an inhibitor of PP-1 or of PKA

external resources
NCBI:1269591
REACTOME:R-HSA-180024
PUBMED:14744247
PUBMED:2908293

genes
CALM1 , CALM2 , CALM3 , CDK5 , PDE4A , PDE4B , PDE4C , PDE4D , PPP1CA , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5D , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PRKACA , PRKACB , PRKACG , PRKAR1A , PRKAR1B , PRKAR2A , PRKAR2B , PPP1R1B , LOC729966 ,