description
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory

external resources
NCBI:101143
KEGG:hsa04722
PUBMED:16699811
PUBMED:10812966
PUBMED:12676795
PUBMED:16939974
PUBMED:10851172
PUBMED:15499580
PUBMED:14704852
PUBMED:11399424
PUBMED:10764727
PUBMED:10985348
PUBMED:16856873
PUBMED:11529497

genes
ABL1 , AKT1 , AKT2 , FASLG , RHOA , ARHGDIA , ARHGDIB , ARHGDIG , ATF4 , BAD , BAX , BCL2 , BDNF , BRAF , CALM1 , CALM2 , CALM3 , CALML3 , CAMK4 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CDC42 , CRK , CRKL , MAPK14 , FOXO3 , GAB1 , GRB2 , RAPGEF1 , GSK3B , HRAS , IKBKB , IRAK1 , IRAK2 , IRS1 , JUN , KRAS , MATK , MAP3K1 , MAP3K3 , MAP3K5 , NFKB1 , NFKBIA , NFKBIB , NFKBIE , NGF , NGFR , NRAS , NTF3 , NTF4 , NTRK1 , NTRK2 , NTRK3 , PDPK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLCG1 , PLCG2 , PRKCD , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K1 , MAP2K2 , MAP2K5 , MAP2K7 , PSEN1 , PSEN2 , PTPN11 , RAC1 , RAF1 , RAP1A , RAP1B , RELA , RPS6KA1 , RPS6KA2 , RPS6KA3 , SORT1 , MAPK12 , SHC1 , SOS1 , SOS2 , TP53 , TP73 , TRAF6 , YWHAE , PIK3R3 , RIPK2 , RPS6KA5 , MAPKAPK2 , MAGED1 , AKT3 , SH2B3 , SH2B2 , ZNF274 , FRS2 , PRDM4 , IRAK3 , SHC2 , SH2B1 , BEX3 , RPS6KA6 , IRAK4 , CALML5 , SHC3 , KIDINS220 , CALML4 , CALML6 , SHC4 ,