description
Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011)

external resources
NCBI:1269593
REACTOME:R-HSA-2179392
PUBMED:16816139
PUBMED:20398727

genes
HBEGF , EGFR , GRB2 , HRAS , KRAS , MMP3 , NRAS , PRKCA , SOS1 ,