description
The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006)

external resources
NCBI:1269596
REACTOME:R-HSA-195253
PUBMED:17143292

genes
AES , APC , CSNK1A1 , CTBP1 , CTBP2 , CTNNB1 , GSK3B , HDAC1 , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , SKP1 , TCF7 , TCF7L2 , TLE1 , TLE2 , TLE3 , TLE4 , UBA52 , UBB , UBC , SEM1 , AXIN1 , CUL1 , BTRC , PSMF1 , PSMD6 , RBX1 , FRAT1 , PSME3 , PSMD14 , PSME4 , FRAT2 , LEF1 , TCF7L1 , PSMB11 , AMER1 , PSMA8 , C7orf76 , LOC100506136 ,