description
The mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, SMRT and NCoR, to the TCF/LEF complex, allowing the transition from activation to repression (Bauer et al, 2000; Weiske et al, 2007; Song and Gelmann, 2008). CTNNBIP1 (also known as ICAT) and Chibby are inhibitors of TCF-dependent signaling that function by binding directly to beta-catenin and preventing interactions with critical components of the transactivation machinery (Takemaru et al, 2003; Li et al, 2008; Tago et al, 2000; Graham et al, 2002; Daniels and Weiss, 2002). Chibby additionally promotes the nuclear export of beta-catenin in conjunction with 14-3-3/YWHAZ proteins (Takemura et al, 2003; Li et al, 2008). A couple of recent studies have also suggested a role for nuclear APC in the disassembly of the beta-catenin activation complex (Hamada and Bienz, 2004; Sierra et al, 2006). It is worth noting that while some of the players involved in the disassembly of the beta-catenin transactivating complex are beginning to be worked out in vitro, the significance of their role in vivo is not yet fully understood, and some can be knocked out with little effect on endogenous WNT signaling (see for instance Voronina et al, 2009)

external resources
NCBI:1269604
REACTOME:R-HSA-3769402
PUBMED:18632669
PUBMED:12408825
PUBMED:18573912
PUBMED:11080158
PUBMED:15525529
PUBMED:16510874
PUBMED:12712206
PUBMED:18077326
PUBMED:19364920
PUBMED:12408824
PUBMED:10898789

genes
AKT1 , AKT2 , APC , XIAP , BCL9 , CTBP1 , CTNNB1 , HDAC1 , MEN1 , RBBP5 , RPS27A , SOX2 , SOX3 , SOX4 , SOX9 , SRY , TCF7 , TCF7L2 , TLE1 , TLE2 , TLE3 , TLE4 , UBA52 , UBB , UBC , XPO1 , YWHAZ , KMT2D , BTRC , ASH2L , SOX13 , CBY1 , PYGO1 , LEF1 , SOX6 , CTNNBIP1 , CHD8 , SOX17 , TCF7L1 , SOX7 , PYGO2 , BCL9L ,