description
DVL protein levels are regulated by both proteasomal and lysosomal degradation (reviewed in Gao and Chen, 2010). The E3 ligases HECF1, ITCH and KLHL12:CUL3 have all been shown to contribute to the polyubiquitination and subsequent degradation of DVL (Angers et al, 2006; Miyazaki et al, 2004; Wei et al, 2012). DVL stability is also regulated by its interaction with DACT1, which promotes degradation of DVL in the lysosome (Cheyette et al, 2002; Zhang et al, 2006)

external resources
NCBI:1269605
REACTOME:R-HSA-4641258
PUBMED:14684739
PUBMED:20006983
PUBMED:22826439
PUBMED:11970895
PUBMED:16547521
PUBMED:16446366

genes
DVL1 , DVL2 , DVL3 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , UBA52 , UBB , UBC , SEM1 , CUL3 , PSMF1 , PSMD6 , RBX1 , PSME3 , PSMD14 , HECW1 , PSME4 , DACT1 , KLHL12 , PSMB11 , PSMA8 , C7orf76 , LOC100506136 ,