description
AXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, however (Lee et al, 2003; Tan et al, 2012). Cellular levels of AXIN are regulated in part through ubiquitin-mediated turnover. E3 ligases SMURF2 and RNF146 have both been shown to play a role in promoting the degradation of AXIN by the 26S proteasome (Kim and Jho, 2010; Callow et al, 2011; Zhang et al, 2011)

external resources
NCBI:1269606
REACTOME:R-HSA-4641257
PUBMED:21478859
PUBMED:14551908
PUBMED:22363759
PUBMED:20858899
PUBMED:21799911

genes
PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , UBA52 , UBB , UBC , SEM1 , AXIN1 , AXIN2 , TNKS , PSMF1 , PSMD6 , PSME3 , PSMD14 , PSME4 , SMURF2 , TNKS2 , RNF146 , PSMB11 , PSMA8 , C7orf76 , LOC100506136 ,