description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type

external resources
NCBI:102279
KEGG:hsa04144
PUBMED:19696797
PUBMED:19007773
PUBMED:16203612
PUBMED:15687999
PUBMED:19924646
PUBMED:15261671
PUBMED:18647649
PUBMED:19325624
PUBMED:20110990
PUBMED:22193161

genes
ADRB1 , ADRB2 , ADRB3 , GRK2 , GRK3 , AP2A1 , AP2A2 , AP2B1 , AMPH , BIN1 , ARF1 , ARF3 , ARF5 , ARF6 , RHOA , ARRB1 , ARRB2 , CAPZA1 , CAPZA2 , CAPZB , CAV1 , CAV2 , CAV3 , CBL , CBLB , CDC42 , AP2M1 , AP2S1 , CLTA , CLTB , CLTC , CCR5 , CSF1R , DAB2 , DNM1 , DNM2 , EGF , EGFR , EPS15 , ERBB3 , ERBB4 , F2R , FGFR3 , FGFR2 , FGFR4 , FLT1 , FOLR1 , FOLR2 , FOLR3 , GRK4 , GRK5 , GRK6 , HLA-A , HLA-B , HLA-C , HLA-E , HLA-F , HLA-G , HRAS , HSPA1A , HSPA1B , HSPA1L , HSPA2 , HSPA6 , HSPA8 , IGF1R , IGF2R , IL2RA , IL2RB , IL2RG , CXCR1 , CXCR2 , KDR , KIF5A , KIF5B , KIF5C , KIT , LDLR , SMAD2 , SMAD3 , MDM2 , RAB8A , MET , NEDD4 , NTRK1 , CHMP1A , PDGFRA , PLD1 , PLD2 , PML , PRKCI , PRKCZ , PSD , RAB4A , RAB5A , RAB5B , RAB5C , RET , GRK1 , SH3GL1 , SH3GL2 , SH3GL3 , SNX1 , SNX2 , SRC , TFRC , TGFB1 , TGFB2 , TGFB3 , TGFBR1 , TGFBR2 , TRAF6 , TSG101 , WAS , WIPF1 , CXCR4 , RAB7A , STAM , CLTCL1 , PIP5K1A , PIP5K1B , EEA1 , SNX4 , SNX3 , GBF1 , RAB11A , ASAP2 , WASL , USP8 , RABEP1 , HGS , RAB11B , CYTH3 , CYTH2 , CYTH1 , ZFYVE9 , VPS4B , VPS26A , RAB11FIP3 , ACAP1 , ZFYVE16 , IST1 , GIT2 , DNAJC6 , WASHC5 , IQSEC1 , PDCD6IP , ARPC5 , ARPC4 , ARPC3 , ARPC1B , ARPC2 , RNF41 , STAM2 , ARPC1A , ARFGEF2 , ARFGEF1 , STAMBP , RAB10 , EHD1 , RAB35 , RAB31 , WWP1 , SNF8 , VPS45 , RAB11FIP2 , EPN2 , IQSEC2 , SPART , WASHC4 , NEDD4L , PSD3 , PIP5K1C , ACAP2 , PSD4 , CBLC , CHMP2B , DNM3 , RAB11FIP5 , LDLRAP1 , ARFGAP3 , CYTH4 , SNX5 , VPS4A , CHMP2A , GIT1 , CHMP4A , EPN1 , SNX12 , SH3KBP1 , EHD4 , EHD3 , EHD2 , ASAP1 , PARD6A , WASHC3 , VPS36 , SH3GLB1 , VPS28 , SPG21 , CHMP5 , VTA1 , CHMP3 , VPS29 , EPN3 , VPS37C , ASAP3 , VPS35 , ARFGAP1 , PARD3 , SH3GLB2 , CHMP1B , SMURF1 , RAB22A , EPS15L1 , SNX6 , SMAP1 , RBSN , ARAP3 , SMAP2 , SMURF2 , CHMP6 , VPS37B , RAB11FIP1 , RUFY1 , ARPC5L , ITCH , PSD2 , VPS25 , ARFGAP2 , RAB11FIP4 , PARD6G , PARD6B , MVB12B , CHMP7 , CHMP4C , MVB12A , CAPZA3 , VPS26B , ACAP3 , ARAP2 , ARAP1 , AGAP2 , AGAP1 , AGAP3 , ZFYVE27 , CHMP4B , GRK7 , VPS37A , PIP5KL1 , WIPF2 , VPS37D , WASHC2C , SNX32 , WASHC2A , IZUMO1R , IQSEC3 , WIPF3 , WASHC1 , RNF103-CHMP3 ,