description
A number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G proteins and promotes calcium release through phophoinositol signaling and activation of phosphodiesterase (PDE). Downstream effectors include the calcium/calmodulin-dependent kinase II (CaMK2) and PKC (reviewed in De, 2011). The WNT Ca2+ pathway is important in dorsoventral polarity, convergent extension and organ formation in vertebrates and also has roles in negatively regulating 'canonical' beta-catenin-dependent transcription. Non-canonical WNT Ca2+ signaling is also implicated in inflammatory response and cancer (reviewed in Kohn and Moon, 2005; Sugimura and Li, 2010)

external resources
NCBI:1269615
REACTOME:R-HSA-4086398
PUBMED:21903638
PUBMED:21181886
PUBMED:16099039

genes
CALM1 , CALM2 , CALM3 , CAMK2A , CTNNB1 , FZD2 , GNAO1 , GNAT2 , GNB1 , GNB2 , GNB3 , GNG3 , GNG4 , GNG5 , GNG7 , GNG10 , GNG11 , GNGT1 , GNGT2 , ITPR1 , ITPR2 , ITPR3 , MOV10 , NFATC1 , PDE6A , PDE6G , PDE6B , PLCB2 , PLCB3 , PPP3CA , PPP3CB , PPP3R1 , PRKCA , PRKG1 , PRKG2 , MAP3K7 , TCF7 , TCF7L2 , WNT5A , WNT11 , FZD5 , FZD3 , FZD4 , FZD6 , GNB5 , TNRC6B , PLCB1 , AGO1 , AGO2 , TNRC6A , LEF1 , NLK , GNG13 , GNG2 , GNG12 , TNRC6C , GNB4 , TCF7L1 , GNG8 , AGO3 , AGO4 ,