description
A number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G proteins and promotes calcium release through phophoinositol signaling and activation of phosphodiesterase (PDE). Downstream effectors include the calcium/calmodulin-dependent kinase II (CaMK2) and PKC (reviewed in De, 2011). The WNT Ca2+ pathway is important in dorsoventral polarity, convergent extension and organ formation in vertebrates and also has roles in negatively regulating 'canonical' beta-catenin-dependent transcription. Non-canonical WNT Ca2+ signaling is also implicated in inflammatory response and cancer (reviewed in Kohn and Moon, 2005; Sugimura and Li, 2010)
external resources
NCBI:1269615
REACTOME:R-HSA-4086398
PUBMED:21903638
PUBMED:21181886
PUBMED:16099039
genes
CALM1
,
CALM2
,
CALM3
,
CAMK2A
,
CTNNB1
,
FZD2
,
GNAO1
,
GNAT2
,
GNB1
,
GNB2
,
GNB3
,
GNG3
,
GNG4
,
GNG5
,
GNG7
,
GNG10
,
GNG11
,
GNGT1
,
GNGT2
,
ITPR1
,
ITPR2
,
ITPR3
,
MOV10
,
NFATC1
,
PDE6A
,
PDE6G
,
PDE6B
,
PLCB2
,
PLCB3
,
PPP3CA
,
PPP3CB
,
PPP3R1
,
PRKCA
,
PRKG1
,
PRKG2
,
MAP3K7
,
TCF7
,
TCF7L2
,
WNT5A
,
WNT11
,
FZD5
,
FZD3
,
FZD4
,
FZD6
,
GNB5
,
TNRC6B
,
PLCB1
,
AGO1
,
AGO2
,
TNRC6A
,
LEF1
,
NLK
,
GNG13
,
GNG2
,
GNG12
,
TNRC6C
,
GNB4
,
TCF7L1
,
GNG8
,
AGO3
,
AGO4
,
