description
Binding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS-RAS-RAF-MAPK (ERK) pathway and the PI3K-PKB (AKT) pathway (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parella et al. 2010, Annunziata et al. 2011, Siddle et al. 2012, Holzenberger 2012)

external resources
NCBI:1269617
REACTOME:R-HSA-2404192
PUBMED:21042815
PUBMED:18927274
PUBMED:20098959
PUBMED:17598937
PUBMED:20975071
PUBMED:22044904
PUBMED:22649417

genes
ACTN2 , AKT1 , AKT2 , ANGPT1 , ARAF , ARRB1 , ARRB2 , BRAF , BTC , CALM1 , CALM2 , CALM3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CSF2 , CSF2RA , CSF2RB , CSK , DLG4 , HBEGF , DUSP1 , DUSP2 , DUSP4 , DUSP5 , DUSP6 , DUSP7 , DUSP8 , DUSP9 , EGF , EGFR , EIF4B , EIF4E , EIF4EBP1 , EIF4G1 , ERBB2 , ERBB3 , ERBB4 , EREG , FGA , FGB , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FGG , FN1 , MTOR , FYN , GAB1 , GDNF , GFRA1 , GFRA2 , GFRA3 , GRB2 , GRIN1 , GRIN2A , GRIN2B , GRIN2C , GRIN2D , HGF , NRG1 , HRAS , IGF1 , IGF1R , IGF2 , IL2 , IL2RA , IL2RB , IL2RG , IL3 , IL3RA , IL5 , IL5RA , IRS1 , ITGA2B , ITGB3 , JAK1 , JAK2 , JAK3 , KIT , KRAS , MARK3 , MET , KITLG , MAP3K11 , NCAM1 , NEFL , NF1 , NRAS , NRTN , PEBP1 , PDE3B , PDGFA , PDGFB , PDGFRA , PDGFRB , PDPK1 , PHB , PIK3C3 , PIK3CA , PIK3CB , PIK3R1 , PIK3R2 , PPM1A , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PPP5C , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKAG1 , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , PSPN , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTK2 , PTPN11 , PTPRA , RAF1 , RAP1A , RAP1B , RASA1 , RASA2 , RASGRF1 , RASGRF2 , RET , RHEB , RPS6 , RPS6KB1 , RPS27A , SHC1 , SOS1 , SPTA1 , SPTAN1 , SPTB , SPTBN1 , SPTBN2 , SRC , STK11 , TEK , TLN1 , TSC1 , TSC2 , UBA52 , UBB , UBC , VCL , VWF , YWHAB , SEM1 , FGF23 , BRAP , RASAL1 , CUL3 , IRS4 , CILP , LAMTOR3 , IRS2 , PEA15 , FGF18 , FGF17 , FGF16 , IQGAP1 , SYNGAP1 , KSR1 , ARTN , KL , RASAL2 , PSMF1 , NRG2 , RAPGEF2 , PSMD6 , FGF19 , RBX1 , RANBP9 , RASGRP1 , AKAP9 , RASA4 , PSME3 , PSMD14 , CNKSR1 , RRAGB , LAMTOR5 , RRAGA , NRG3 , FRS3 , FRS2 , DUSP10 , RASA3 , CNKSR2 , PSME4 , SHC2 , RASGRP3 , FGF20 , FGF22 , LAT , LAMTOR2 , EEF2K , PIK3R4 , SPTBN5 , PRKAG2 , CAB39 , SHC3 , PRKAG3 , TLR9 , APBB1IP , IL17RD , LAMTOR1 , STRADB , RPTOR , SPTBN4 , TRIB3 , RRAGD , GFRA4 , RRAGC , MLST8 , RASAL3 , DUSP16 , CAB39L , KBTBD7 , WDR83 , AKT1S1 , STRADA , RASGRP4 , THEM4 , PSMB11 , PSMA8 , NRG4 , PAQR3 , KLB , DAB2IP , SPRED1 , SPRED2 , RASGEF1A , KSR2 , LAMTOR4 , SPRED3 , C7orf76 , LOC100506136 , MIR5004 ,