description
Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling

external resources
NCBI:1269619
REACTOME:R-HSA-2428933
PUBMED:18927274
PUBMED:20098959
PUBMED:17598937
PUBMED:20975071
PUBMED:22649417

genes
GRB2 , HRAS , IGF1 , IGF1R , IGF2 , KRAS , NRAS , SHC1 , SOS1 ,