description
The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling

external resources
NCBI:1269620
REACTOME:R-HSA-2428928
PUBMED:17598937
PUBMED:20975071
PUBMED:22649417
PUBMED:18927274
PUBMED:21042815
PUBMED:20098959

genes
ACTN2 , AKT1 , AKT2 , ANGPT1 , ARAF , ARRB1 , ARRB2 , BRAF , BTC , CALM1 , CALM2 , CALM3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CSF2 , CSF2RA , CSF2RB , CSK , DLG4 , HBEGF , DUSP1 , DUSP2 , DUSP4 , DUSP5 , DUSP6 , DUSP7 , DUSP8 , DUSP9 , EGF , EGFR , EIF4B , EIF4E , EIF4EBP1 , EIF4G1 , ERBB2 , ERBB3 , ERBB4 , EREG , FGA , FGB , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FGG , FN1 , MTOR , FYN , GAB1 , GDNF , GFRA1 , GFRA2 , GFRA3 , GRB2 , GRIN1 , GRIN2A , GRIN2B , GRIN2C , GRIN2D , HGF , NRG1 , HRAS , IGF1 , IGF1R , IGF2 , IL2 , IL2RA , IL2RB , IL2RG , IL3 , IL3RA , IL5 , IL5RA , IRS1 , ITGA2B , ITGB3 , JAK1 , JAK2 , JAK3 , KIT , KRAS , MARK3 , MET , KITLG , MAP3K11 , NCAM1 , NEFL , NF1 , NRAS , NRTN , PEBP1 , PDE3B , PDGFA , PDGFB , PDGFRA , PDGFRB , PDPK1 , PHB , PIK3C3 , PIK3CA , PIK3CB , PIK3R1 , PIK3R2 , PPM1A , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PPP5C , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKAG1 , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , PSPN , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTK2 , PTPN11 , PTPRA , RAF1 , RAP1A , RAP1B , RASA1 , RASA2 , RASGRF1 , RASGRF2 , RET , RHEB , RPS6 , RPS6KB1 , RPS27A , SHC1 , SOS1 , SPTA1 , SPTAN1 , SPTB , SPTBN1 , SPTBN2 , SRC , STK11 , TEK , TLN1 , TSC1 , TSC2 , UBA52 , UBB , UBC , VCL , VWF , YWHAB , SEM1 , FGF23 , BRAP , RASAL1 , CUL3 , IRS4 , LAMTOR3 , IRS2 , PEA15 , FGF18 , FGF17 , FGF16 , IQGAP1 , SYNGAP1 , KSR1 , ARTN , KL , RASAL2 , PSMF1 , NRG2 , RAPGEF2 , PSMD6 , FGF19 , RBX1 , RANBP9 , RASGRP1 , AKAP9 , RASA4 , PSME3 , PSMD14 , CNKSR1 , RRAGB , LAMTOR5 , RRAGA , NRG3 , FRS3 , FRS2 , DUSP10 , RASA3 , CNKSR2 , PSME4 , SHC2 , RASGRP3 , FGF20 , FGF22 , LAT , LAMTOR2 , EEF2K , PIK3R4 , SPTBN5 , PRKAG2 , CAB39 , SHC3 , PRKAG3 , TLR9 , APBB1IP , IL17RD , LAMTOR1 , STRADB , RPTOR , SPTBN4 , TRIB3 , RRAGD , GFRA4 , RRAGC , MLST8 , RASAL3 , DUSP16 , CAB39L , KBTBD7 , WDR83 , AKT1S1 , STRADA , RASGRP4 , THEM4 , PSMB11 , PSMA8 , NRG4 , PAQR3 , KLB , DAB2IP , SPRED1 , SPRED2 , RASGEF1A , KSR2 , LAMTOR4 , SPRED3 , C7orf76 , LOC100506136 , MIR5004 ,