description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034]

external resources
NCBI:104488
KEGG:hsa00270
PUBMED:18391471
PUBMED:14551435
PUBMED:15102328
PUBMED:12644499
PUBMED:12670965
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PUBMED:19270684
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PUBMED:10613873
PUBMED:18520135
PUBMED:12022921

genes
AHCY , AMD1 , BCAT1 , BCAT2 , BHMT , CBS , CDO1 , CTH , DNMT1 , DNMT3A , DNMT3B , GCLC , GCLM , GOT1 , GOT2 , GSS , LDHA , LDHB , LDHC , MAT1A , MAT2A , MDH1 , MDH2 , MPST , MTAP , MTR , SMS , SRM , TAT , TST , AHCYL1 , SDS , AHCYL2 , BHMT2 , MAT2B , APIP , ADI1 , ENOPH1 , AGXT2 , MRI1 , LDHAL6B , SDSL , LDHAL6A , IL4I1 ,