description
In the absence of Hh signaling, the majority of full-length GLI3 is partially processed by the proteasome to a shorter form that serves as the principal repressor of Hh target genes (Wang et al, 2000). Processing depends on phosphorylation at 6 sites by PKA, which primes the protein for subsequent phosphorylation at adjacent sites by CK1 and GSK3. The hyperphosphorylated protein is then a direct target for betaTrCP-dependent ubiquitination and proteasome-dependent processing (Wang and Li, 2006; Tempe et al, 2006; Wen et al, 2010; Schrader et al, 2011; Pan and Wang, 2007)

external resources
NCBI:1269637
REACTOME:R-HSA-5610785
PUBMED:21921029
PUBMED:20154143
PUBMED:16371461
PUBMED:10693759
PUBMED:16705181
PUBMED:17283082

genes
CSNK1A1 , GLI3 , GSK3B , PRKACA , PRKACB , PRKACG , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , SKP1 , UBA52 , UBB , UBC , SEM1 , CUL1 , BTRC , PSMF1 , PSMD6 , RBX1 , PSME3 , PSMD14 , PSME4 , SUFU , PSMB11 , PSMA8 , C7orf76 , LOC100506136 ,