description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes

external resources
NCBI:114228
KEGG:hsa04666
PUBMED:11304556
PUBMED:11244038
PUBMED:10755615
PUBMED:17308335
PUBMED:12821647
PUBMED:15466916
PUBMED:17050193
PUBMED:11228151
PUBMED:12488490
PUBMED:10224668
PUBMED:11708889
PUBMED:9581795
PUBMED:10586078
PUBMED:9417101
PUBMED:15485887
PUBMED:18322649
PUBMED:10577498
PUBMED:10376013
PUBMED:10601359
PUBMED:9545263

genes
AKT1 , AKT2 , AMPH , BIN1 , ARF6 , CDC42 , CFL1 , CFL2 , CRK , CRKL , DNM2 , DOCK2 , FCGR1A , FCGR2A , FCGR2B , FCGR3A , GSN , HCK , INPP5D , INPPL1 , LIMK1 , LIMK2 , LYN , MARCKS , MYO10 , PAK1 , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLA2G4A , PLCG1 , PLCG2 , PLD1 , PLD2 , PRKCA , PRKCB , PRKCD , PRKCE , PRKCG , MAPK1 , MAPK3 , MAP2K1 , PTPRC , RAC1 , RAC2 , RAF1 , RPS6KB1 , RPS6KB2 , SYK , VASP , VAV1 , VAV2 , WAS , PIP5K1A , PIP5K1B , PLA2G6 , PIK3R3 , PLPP1 , PLPP2 , PLPP3 , ASAP2 , SPHK1 , WASF1 , WASL , GAB2 , AKT3 , ARPC5 , ARPC4 , ARPC3 , ARPC1B , ARPC2 , WASF2 , VAV3 , ARPC1A , WASF3 , PIP5K1C , LAT , ASAP1 , ASAP3 , SPHK2 , MARCKSL1 , ARPC5L , SCIN , PLA2G4E , PLA2G4F , PLA2G4D , NCF1 , PLA2G4B ,