description
The tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many genes involved in a variety of cellular processes, such as cellular metabolism, survival, senescence, apoptosis and DNA damage response. Because of its critical function, p53 is frequently mutated in around 50% of all malignant tumors. For a recent review, please refer to Vousden and Prives 2009 and Kruiswijk et al. 2015

external resources
NCBI:1269654
REACTOME:R-HSA-3700989
PUBMED:26122615
PUBMED:19410540

genes
AKT1 , AKT2 , APAF1 , BIRC5 , FAS , ATM , ATR , BARD1 , BAX , BCL6 , BID , PRDM1 , BLM , BNIP3L , BRCA1 , CASP1 , CASP2 , CASP6 , CASP10 , CCNA2 , CCNB1 , CCNE1 , CCNG1 , CCNH , CCNT1 , CCNT2 , CDK1 , CDC25C , CDK2 , CDK5 , CDK7 , CDK9 , CDKN1A , CDKN1B , CDKN2A , CHD3 , CHD4 , CHEK1 , CHM , PLK3 , COX4I1 , COX5B , COX6A1 , COX6B1 , COX6C , COX7B , COX7C , COX8A , COX11 , ATF2 , CREBBP , MAPK14 , CSNK2A1 , CSNK2A2 , CSNK2B , DAXX , DDB2 , GADD45A , DNA2 , ARID3A , E2F1 , E2F4 , EP300 , ERCC2 , ERCC3 , FANCC , FANCD2 , FOS , MTOR , G6PD , GLS , SFN , GPI , GPX2 , GSR , GTF2F1 , GTF2F2 , GTF2H1 , GTF2H2 , GTF2H3 , GTF2H4 , HDAC1 , HDAC2 , PRMT1 , HUS1 , IGFBP3 , ING2 , JUN , MDM2 , MDM4 , MLH1 , MNAT1 , MOV10 , MRE11 , MSH2 , MT-CO1 , MT-CO2 , MT-CO3 , NBN , NDUFA4 , CNOT2 , CNOT3 , CNOT4 , NPM1 , PRDX1 , PCNA , PDPK1 , PIN1 , PIP4K2A , PLAGL1 , PMAIP1 , PML , PMS2 , POLR2A , POLR2B , POLR2C , POLR2D , POLR2E , POLR2F , POLR2G , POLR2H , POLR2I , POLR2J , POLR2K , POLR2L , POU4F1 , POU4F2 , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R5C , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKAG1 , MAPK11 , MAP2K6 , PTEN , RAD1 , RABGGTA , RABGGTB , RAD9A , RAD17 , RAD51D , RBBP4 , RBBP7 , RBBP8 , RBL1 , RBL2 , RFC2 , RFC3 , RFC4 , RFC5 , RHEB , RPA1 , RPA2 , RPA3 , RPS27A , SCO1 , SGK1 , SSRP1 , AURKA , STK11 , SUPT4H1 , SUPT5H , SURF1 , TAF1 , TAF2 , TAF4 , TAF4B , TAF5 , TAF6 , TAF7 , TAF9 , TAF10 , TAF11 , TAF12 , TAF13 , TBP , TCEA1 , ELOC , ELOB , ELOA , PRDX2 , TFDP1 , TFDP2 , TOP3A , TP53 , TP53BP2 , TP73 , TSC1 , TSC2 , TXN , TXNRD1 , UBA52 , UBB , UBC , NELFA , WRN , YWHAB , YWHAE , YWHAG , YWHAH , YWHAZ , BTG2 , BRPF1 , USP7 , NELFE , KAT6A , ELL , PIP4K2B , DYRK2 , MAPKAPK5 , CDK13 , TP63 , LAMTOR3 , CRADD , TNFRSF10D , TNFRSF10C , TNFRSF10B , TNFRSF10A , CCNK , CDK5R1 , CCNA1 , USP2 , CNOT9 , CCNE2 , CTDP1 , EXO1 , COX7A2L , AURKB , MTA2 , CNOT8 , COX5A , TP53I3 , MDC1 , NUAK1 , SCO2 , AKT3 , RAD50 , LRPPRC , RRAGB , NDRG1 , PRMT5 , CARM1 , KAT5 , LAMTOR5 , PRELID3A , RRAGA , PLK2 , PPP1R13L , EHMT2 , YWHAQ , TOPBP1 , SUPT16H , CHEK2 , TPX2 , CNOT1 , TNRC6B , PPP1R13B , BRD1 , PRDX5 , CNOT10 , NELFB , ZNF385A , L3MBTL1 , NOC2L , AGO1 , BBC3 , BRPF3 , AGO2 , GLS2 , PRELID1 , SESN1 , TNRC6A , LAMTOR2 , RGCC , HIPK2 , BRD7 , CNOT7 , RRM2B , TACO1 , ELOA2 , PHF20 , COX16 , PRKAG2 , NELFCD , TRIAP1 , TAF9B , CDK12 , MBD3 , PRKAG3 , CYCS , TAF7L , DDIT4 , GATAD2A , BANP , LAMTOR1 , FANCI , STEAP3 , PIDD1 , CNOT11 , PRR5 , CENPJ , SMYD2 , PCBP4 , TIGAR , GATAD2B , CNOT6 , RPTOR , TNRC6C , NLRC4 , RRAGD , TP53AIP1 , PERP , RRAGC , MLST8 , MEAF6 , MAPKAP1 , BCL2L14 , EHMT1 , PIP4K2C , RMI1 , RNF34 , SESN2 , RHNO1 , TAF3 , BRIP1 , ATRIP , ING5 , AIFM2 , COX14 , TNKS1BP1 , PIP4P1 , TTC5 , TP53INP1 , TP53RK , RMI2 , COX20 , RFFL , TMEM219 , SETD9 , JMY , TAF1L , SESN3 , E2F7 , RAD9B , ZNF420 , ELOA3 , AGO3 , AGO4 , HIPK1 , CNOT6L , RICTOR , COX18 , KMT5A , LAMTOR4 , GTF2H5 , ELOA3B , MIR943 , MIR1257 , MIR1281 , MIR1236 , MIR3191 , MIR2861 , MIR3607 , ELOA3D , MIR4741 , MIR3960 ,