description
During initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymerase I to the SL1:phosphorlated UBF-1:rDNA promoter complex.Mammalian rRNA genes are preceded by a terminator element that is recognized by the SL1 complex. This SL1 modulated acetylation of the basal Pol I transcription machinery has functional consequences suggesting that the reversible acetylation may be one way to regulate rDNA transcription

external resources
NCBI:1269660
REACTOME:R-HSA-73762

genes
CCNH , CDK7 , CHD3 , CHD4 , ERCC2 , ERCC3 , ERCC6 , KAT2A , GTF2H1 , GTF2H2 , GTF2H3 , GTF2H4 , HDAC1 , HDAC2 , MNAT1 , POLR2E , POLR2F , POLR2H , POLR2K , POLR2L , RBBP4 , RBBP7 , TBP , TTF1 , UBTF , KAT2B , TAF1C , TAF1B , TAF1A , MTA1 , MTA2 , POLR1C , CD3EAP , EHMT2 , POLR1A , ZNRD1 , POLR1D , MBD3 , RRN3 , GATAD2A , GATAD2B , MTA3 , POLR1E , TAF1D , POLR1B , TWISTNB , GTF2H5 , MIR1304 ,