description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses

external resources
NCBI:117292
KEGG:hsa04622
PUBMED:19224920
PUBMED:19076341
PUBMED:18549796
PUBMED:18591413
PUBMED:19615405
PUBMED:19120475
PUBMED:18439848
PUBMED:19120476
PUBMED:15208624
PUBMED:19539500
PUBMED:18272355
PUBMED:18984593

genes
CASP8 , CASP10 , CHUK , MAPK14 , CYLD , DDX3X , IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNB1 , IFNW1 , IKBKB , CXCL8 , IL12A , IL12B , CXCL10 , IRF3 , IRF7 , MAP3K1 , NFKB1 , NFKBIA , NFKBIB , PIN1 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , RELA , MAPK12 , MAP3K7 , TNF , TRAF2 , TRAF3 , TRAF6 , TRIM25 , IKBKG , TRADD , RIPK1 , FADD , ATG12 , ATG5 , ISG15 , IKBKE , TBKBP1 , TANK , DDX58 , TKFC , TBK1 , RNF125 , OTUD5 , IFNK , MAVS , IFIH1 , AZI2 , DHX58 , NLRX1 , SIKE1 , IFNE , TMEM173 ,