description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP
external resources
NCBI:119304
KEGG:hsa04914
PUBMED:10497333
PUBMED:12084906
PUBMED:12045215
PUBMED:11063930
PUBMED:12477927
PUBMED:11148128
PUBMED:11730319
PUBMED:12374568
genes
ADCY1
,
ADCY2
,
ADCY3
,
ADCY5
,
ADCY6
,
ADCY7
,
ADCY8
,
ADCY9
,
AKT1
,
AKT2
,
ARAF
,
BRAF
,
BUB1
,
CCNA2
,
CCNB1
,
CDK1
,
CDC25A
,
CDC25B
,
CDC25C
,
CDC27
,
CDK2
,
MAPK14
,
GNAI1
,
GNAI2
,
GNAI3
,
HSP90AA1
,
HSP90AB1
,
IGF1
,
IGF1R
,
INS
,
KRAS
,
MAD2L1
,
MOS
,
PDE3B
,
PGR
,
PIK3CA
,
PIK3CB
,
PIK3CD
,
PIK3R1
,
PIK3R2
,
PLK1
,
PRKACA
,
PRKACB
,
PRKACG
,
MAPK1
,
MAPK3
,
MAPK8
,
MAPK11
,
MAPK9
,
MAPK10
,
MAPK13
,
MAP2K1
,
RAF1
,
RPS6KA1
,
RPS6KA2
,
RPS6KA3
,
MAPK12
,
MAD1L1
,
PIK3R3
,
CDC23
,
CDC16
,
CCNA1
,
PKMYT1
,
CCNB2
,
AKT3
,
ANAPC10
,
MAD2L2
,
CPEB3
,
ANAPC13
,
RPS6KA6
,
ANAPC2
,
ANAPC4
,
FZR1
,
ANAPC5
,
ANAPC7
,
ANAPC11
,
CPEB1
,
ANAPC1
,
CPEB4
,
CCNB3
,
CPEB2
,
ADCY4
,
SPDYA
,
CDC26
,
SPDYE1
,
SPDYC
,
SPDYE4
,
SPDYE3
,
SPDYE2
,
SPDYE5
,
SPDYE6
,
SPDYE2B
,
