description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP

external resources
NCBI:119304
KEGG:hsa04914
PUBMED:10497333
PUBMED:12084906
PUBMED:12045215
PUBMED:11063930
PUBMED:12477927
PUBMED:11148128
PUBMED:11730319
PUBMED:12374568

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , AKT1 , AKT2 , ARAF , BRAF , BUB1 , CCNA2 , CCNB1 , CDK1 , CDC25A , CDC25B , CDC25C , CDC27 , CDK2 , MAPK14 , GNAI1 , GNAI2 , GNAI3 , HSP90AA1 , HSP90AB1 , IGF1 , IGF1R , INS , KRAS , MAD2L1 , MOS , PDE3B , PGR , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLK1 , PRKACA , PRKACB , PRKACG , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K1 , RAF1 , RPS6KA1 , RPS6KA2 , RPS6KA3 , MAPK12 , MAD1L1 , PIK3R3 , CDC23 , CDC16 , CCNA1 , PKMYT1 , CCNB2 , AKT3 , ANAPC10 , MAD2L2 , CPEB3 , ANAPC13 , RPS6KA6 , ANAPC2 , ANAPC4 , FZR1 , ANAPC5 , ANAPC7 , ANAPC11 , CPEB1 , ANAPC1 , CPEB4 , CCNB3 , CPEB2 , ADCY4 , SPDYA , CDC26 , SPDYE1 , SPDYC , SPDYE4 , SPDYE3 , SPDYE2 , SPDYE5 , SPDYE6 , SPDYE2B ,