description
Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. Genetically inherited forms of DCM ("familial" DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM. The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an "idiopathic" DCM. Current hypotheses regarding causes of "idiopathic" DCM focus on myocarditis induced by enterovirus and subsequent autoimmune myocardium impairments. Antibodies to the beta1-adrenergic receptor (beta1AR), which are detected in a substantial number of patients with "idiopathic" DCM, may increase the concentration of intracellular cAMP and intracellular Ca2+, a condition often leading to a transient hyper-performance of the heart followed by depressed heart function and heart failure

external resources
NCBI:121494
KEGG:hsa05414
PUBMED:11524405
PUBMED:11805847
PUBMED:12270949
PUBMED:14522402
PUBMED:19017683
PUBMED:15146239
PUBMED:18672201
PUBMED:19273156
PUBMED:19246813
PUBMED:11716909
PUBMED:16817756

genes
ACTB , ACTC1 , ACTG1 , ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ADRB1 , ATP2A2 , CACNA1C , CACNA1D , CACNA1F , CACNA1S , CACNA2D1 , CACNB1 , CACNB2 , CACNB3 , CACNB4 , CACNG1 , DAG1 , DES , DMD , EMD , GNAS , IGF1 , ITGA6 , ITGA1 , ITGA2 , ITGA2B , ITGA3 , ITGA4 , ITGA5 , ITGA7 , ITGA9 , ITGAV , ITGB1 , ITGB3 , ITGB4 , ITGB5 , ITGB6 , ITGB7 , ITGB8 , LAMA2 , LMNA , MYBPC3 , MYH6 , MYH7 , MYL2 , MYL3 , PLN , PRKACA , PRKACB , PRKACG , RYR2 , SGCA , SGCB , SGCD , SGCG , SLC8A1 , TGFB1 , TGFB2 , TGFB3 , TNF , TNNC1 , TNNI3 , TNNT2 , TPM1 , TPM2 , TPM3 , TPM4 , TTN , ITGA10 , ITGA8 , CACNA2D2 , CACNG3 , CACNG2 , ITGA11 , CACNG5 , CACNG4 , CACNA2D3 , CACNG8 , CACNG7 , CACNG6 , CACNA2D4 , ADCY4 ,