description
Cytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthetases, those specific for arginine, aspartate, glutamate and proline, glutamine, isoleucine, leucine, lysine, and methionine, associate to form a complex with three accessory proteins. Each of the component synthetases is active in vitro as a purified protein; complex formation is thought to channel aminoacylated tRNAs more efficiently to the site of protein synthesis in mRNA:ribosome complexes (Quevillon et al. 1999; Wolfe et al. 2003, 2005)

external resources
NCBI:1269710
REACTOME:R-HSA-379716
PUBMED:16169847
PUBMED:14500886
PUBMED:9878398

genes
AARS , CARS , DARS , EPRS , FARSA , GARS , HARS , IARS , KARS , MARS , NARS , PPA1 , QARS , RARS , SARS , TARS , VARS , WARS , AIMP2 , YARS , AIMP1 , EEF1E1 , FARSB , LARS ,