description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis

external resources
NCBI:122191
KEGG:hsa04621
PUBMED:25330206
PUBMED:21575908
PUBMED:23846113
PUBMED:26549800
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PUBMED:25526305
PUBMED:26121197
PUBMED:22430786

genes
BIRC2 , BIRC3 , XIAP , RHOA , BCL2 , BCL2L1 , CAMP , CASP1 , CASP4 , CASP5 , CASP8 , CASR , CHUK , MAPK14 , CTSB , CYBA , CYBB , GBP1 , GBP2 , GBP3 , CXCL1 , CXCL2 , CXCL3 , HSP90AA1 , HSP90AB1 , IFI16 , IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNAR1 , IFNAR2 , IFNB1 , IKBKB , IL1B , IL6 , CXCL8 , IL18 , IRF3 , IRF7 , ITPR1 , ITPR2 , ITPR3 , JAK1 , JUN , MEFV , MYD88 , NAIP , NFKB1 , NFKBIA , NFKBIB , OAS1 , OAS2 , OAS3 , P2RX7 , PLCB2 , PLCB3 , PLCB4 , PRKCD , MAPK1 , MAPK3 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , RELA , RNASEL , MAPK12 , CCL2 , CCL5 , STAT1 , STAT2 , MAP3K7 , TLR4 , TNF , TNFAIP3 , TP53BP1 , TRAF2 , TRAF3 , TRAF5 , TRAF6 , TRIP6 , TRPM2 , TXN , TYK2 , VDAC1 , VDAC2 , VDAC3 , IKBKG , RIPK1 , RIPK2 , FADD , PSTPIP1 , ATG12 , AIM2 , ATG5 , IKBKE , MFN2 , TANK , DNM1L , NAMPT , IRF9 , NOD1 , TAB1 , RBCK1 , TXNIP , SUGT1 , RIPK3 , GABARAP , GABARAPL2 , NLRP1 , CARD8 , TAB2 , PLCB1 , GABARAPL1 , PANX1 , TXN2 , NOX1 , PYCARD , TBK1 , NOX3 , IRAK4 , TRPV2 , TRPM7 , ATG16L1 , RNF31 , MFN1 , ERBIN , DHX33 , MAVS , NLRC4 , CARD18 , NOD2 , CARD9 , BRCC3 , NLRX1 , GSDMD , SHARPIN , ANTXR1 , CARD6 , MCU , NLRP12 , NLRP3 , CARD16 , GBP4 , GBP5 , ANTXR2 , NEK7 , TICAM1 , PYDC2 , NLRP6 , NLRP7 , GPRC6A , TAB3 , PYDC1 , TMEM173 , GBP7 , CARD17 , CASP12 ,