description
Small RNAs act with components of the RNA-induced silencing complex (RISC) to post-transcriptionally repress expression of mRNAs (reviewed in Nowotny and Yang 2009, Chua et al. 2009). Two mechanisms exist: 1) cleavage of target RNAs by complexes containing Argonaute2 (AGO2, EIF2C2) and a guide RNA that exactly matches the target mRNA and 2) inhibition of translation of target RNAs by complexes containing AGO2 and an inexactly matching guide RNA or by complexes containing a nonendonucleolytic Argonaute (AGO1 (EIF2C1), AGO3 (EIF2C3), or AGO4 (EIF2C4)) and a guide RNA of exact or inexact match. Small interfering RNAs (siRNAs) and microRNAs (miRNAs) can serve as guide RNAs in both types of mechanism. RNAi also appears to direct chromatin modifications that cause transcriptional gene silencing (reviewed in Verdel et al. 2009)

external resources
NCBI:1269722
REACTOME:R-HSA-426496
PUBMED:12154197
PUBMED:19174539
PUBMED:19412884
PUBMED:16510870
PUBMED:17560368
PUBMED:19239886
PUBMED:17632058
PUBMED:19330724
PUBMED:26077373
PUBMED:15260970
PUBMED:15284456
PUBMED:19477631
PUBMED:17197185
PUBMED:18692607
PUBMED:17128271

genes
TNRC6B , AGO1 , AGO2 , TNRC6A , TNRC6C , AGO3 , AGO4 ,