description
Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA differs from the other snRNAs; it binds seven Sm-like proteins and its assembly does not involve a cytoplasmic phase. The snRNP biogenesis pathway for all of the other snRNAs is complex, involving nuclear export of snRNA, Sm-core assembly in the cytoplasm and re-import of the mature snRNP. The assembly of the snRNA:Sm-core is carried out by the survival of motor neurons (SMN) complex. The SMN complex stringently scrutinizes RNAs for specific features that define them as snRNAs and binds the RNA-binding Sm proteins

external resources
NCBI:1269732
REACTOME:R-HSA-191859
PUBMED:15130578

genes
CLNS1A , NCBP1 , NUP88 , NUP98 , RANBP2 , SMN1 , SMN2 , SNRPB , SNRPD1 , SNRPD2 , SNRPD3 , SNRPE , SNRPF , SNRPG , TPR , NUP214 , AAAS , RAE1 , GEMIN2 , NUP155 , NUP93 , NUP58 , POM121 , NUP153 , SNUPN , PRMT5 , NUP50 , NUPL2 , DDX20 , NCBP2 , NUP205 , NUP210 , NUP160 , NUP188 , NUP62 , GEMIN5 , GEMIN4 , PHAX , NUP54 , GEMIN8 , NDC1 , NUP133 , NUP107 , NUP37 , WDR77 , GEMIN7 , GEMIN6 , NUP85 , SEH1L , TGS1 , NUP35 , NUP43 , POM121C ,