description
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell

external resources
NCBI:125137
KEGG:hsa04623
PUBMED:18573338
PUBMED:19665965
PUBMED:19567913
PUBMED:18280611
PUBMED:18724932
PUBMED:19497760
PUBMED:16286919
PUBMED:19122387
PUBMED:19590578
PUBMED:23258413
PUBMED:18375758
PUBMED:19321146
PUBMED:19362700
PUBMED:18941233
PUBMED:19767723

genes
ADAR , POLR3D , CASP1 , CHUK , IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 , IFNB1 , IKBKB , IL1B , IL6 , IL18 , CXCL10 , IRF3 , IRF7 , NFKB1 , NFKBIA , NFKBIB , POLR2E , POLR2F , POLR2H , POLR2K , POLR2L , RELA , CCL4 , CCL5 , IKBKG , RIPK1 , AIM2 , POLR1C , CCL4L2 , IKBKE , POLR3F , POLR3G , POLR3C , RIPK3 , POLR3A , TREX1 , DDX58 , PYCARD , TBK1 , POLR1D , POLR3K , POLR3B , POLR3E , MAVS , ZBP1 , POLR3GL , IL33 , CGAS , POLR3H , TMEM173 , CCL4L1 ,