description
Transcription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughly 400 rRNA genes are expressed and these have the modifications of active chromatin: unmethylated DNA and acetylated histones. Repressed genes generally have methylated DNA and histone H3 methylated at lysine-9. Regulators of repression include the eNoSC complex, SIRT1, and the NoRC complex

external resources
NCBI:1269737
REACTOME:R-HSA-5250941
PUBMED:23063748
PUBMED:23150253
PUBMED:18616426

genes
CCNH , CDK7 , DNMT1 , DNMT3B , ERCC2 , ERCC3 , GTF2H1 , GTF2H2 , GTF2H3 , GTF2H4 , HIST1H2AE , HIST1H2AD , H2AFX , H2AFZ , HIST1H2BD , HIST1H2BB , H3F3A , H3F3B , HDAC1 , HDAC2 , MNAT1 , POLR2E , POLR2F , POLR2H , POLR2K , POLR2L , SUV39H1 , TBP , TTF1 , UBTF , HIST1H4I , HIST1H2AJ , HIST1H2AC , HIST1H2AB , HIST2H2AA3 , HIST2H2AC , HIST1H2BG , HIST1H2BL , HIST1H2BN , HIST1H2BM , HIST1H2BF , HIST1H2BE , HIST1H2BH , HIST1H2BI , HIST1H2BC , HIST1H2BO , HIST2H2BE , HIST1H3A , HIST1H3D , HIST1H3C , HIST1H3E , HIST1H3I , HIST1H3G , HIST1H3J , HIST1H3H , HIST1H3B , HIST1H4A , HIST1H4D , HIST1H4F , HIST1H4K , HIST1H4J , HIST1H4C , HIST1H4H , HIST1H4B , HIST1H4E , HIST1H4L , HIST2H4A , SMARCA5 , SAP30 , MBD2 , HIST1H3F , HIST1H2BJ , TAF1C , TAF1B , TAF1A , POLR1C , SAP18 , CD3EAP , BAZ2A , SIN3B , RRP8 , SIRT1 , POLR1A , SIN3A , SAP30BP , ZNRD1 , POLR1D , ARID4B , H2AFJ , POLR1E , SUDS3 , TAF1D , SAP130 , SAP30L , POLR1B , HIST1H2BK , H2AFV , HIST4H4 , HIST2H3C , HIST3H2BB , TWISTNB , HIST1H2BA , HIST2H3A , GTF2H5 , H2AFB1 , HIST2H4B , HIST2H3D , HIST2H2AA4 , MIR1304 , MIR4738 ,