description
The arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbitz et al, 1992). P53 is rapidly induced in response to damaged DNA. A number of kinases, phosphatases, histone acetylases and ubiquitin-conjugating enzymes regulate the stability as well as transcriptional activity of p53 after DNA damage

external resources
NCBI:1269744
REACTOME:R-HSA-69580
PUBMED:1323840

genes
ATM , CCNA2 , CCNE1 , CDK2 , CDKN1A , CDKN1B , MDM2 , MDM4 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , TP53 , UBA52 , UBB , UBC , SEM1 , CCNA1 , CCNE2 , PSMF1 , PSMD6 , PSME3 , PSMD14 , CHEK2 , PSME4 , ZNF385A , PCBP4 , COP1 , PSMB11 , PSMA8 , C7orf76 , LOC100506136 ,