description
The signal from unattached kinetochores is amplified through a Mad2 inhibitory signal that is propagated by the binding of Mad1 to the kinetochore, the association of Mad2 with Mad1, the conversion of Mad2 conformation to an inhibitory form through its association with Mad1 and finally the release of the inhibitory form of Mad2 from the kinetochore

external resources
NCBI:1269760
REACTOME:R-HSA-141444
PUBMED:14593737

genes
MAD2L1 , MAD1L1 ,