description
The target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there are two proposed mechanism by which inhibition of the APC/C is achieved. These mechanisms differ depending on the mechanism of signal transduction. The APC/C may be inhibited directly by association with the Mitotic Checkpoint Complex (MCC) or through the sequestration of its activator, Cdc20

external resources
NCBI:1269761
REACTOME:R-HSA-141405
PUBMED:14593737

genes
BUB1B , CDC20 , CDC27 , MAD2L1 , UBE2D1 , UBE2E1 , CDC23 , CDC16 , BUB3 , ANAPC10 , UBE2C , ANAPC15 , ANAPC2 , ANAPC4 , ANAPC5 , ANAPC7 , ANAPC11 , ANAPC1 , ANAPC16 , CDC26 ,