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description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes

external resources
NCBI:128760
KEGG:hsa04672
PUBMED:18483500
PUBMED:18838301
PUBMED:15971106
PUBMED:18243016
PUBMED:19079167
PUBMED:18549797
PUBMED:19079156
PUBMED:17161619
PUBMED:17182536
PUBMED:12511876

genes
TNFRSF17 , CD28 , CD80 , CD86 , CD40 , CD40LG , CCR10 , HLA-DMA , HLA-DMB , HLA-DOA , HLA-DOB , HLA-DPA1 , HLA-DPB1 , HLA-DQA1 , HLA-DQA2 , HLA-DQB1 , HLA-DRA , HLA-DRB1 , HLA-DRB5 , IL2 , IL4 , IL5 , IL6 , IL10 , IL15 , IL15RA , ITGA4 , ITGB7 , LTBR , PIGR , CCL25 , CXCL12 , TGFB1 , CXCR4 , MADCAM1 , TNFSF13 , MAP3K14 , TNFSF13B , CCR9 , ICOSLG , TNFRSF13B , ICOS , CCL28 , AICDA , TNFRSF13C ,