description
Cyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include proteins involved in the initiation of DNA replication. The two Cyclin E proteins are subjected to ubiquitin-dependent proteolysis, under the control of an E3 ubiquitin ligase known as the SCF. Cyclin A - Cdk2 complexes, which are also regulated by p21Cip1/Waf1 and p27kip1, are likely to be important for continued DNA synthesis, and progression into G2. An additional level of control of Cdk2 is reversible phosphorylation of Threonine-14 (T14) and Tyrosine-15 (Y15), catalyzed by the Wee1 and Myt1 kinases, and dephosphorylation by the three Cdc25 phosphatases, Cdc25A, B and C

external resources
NCBI:1269768
REACTOME:R-HSA-69206

genes
AKT1 , AKT2 , CCND1 , CCNA2 , CCNB1 , CCNE1 , CCNH , CDK1 , CDC6 , CDC25A , CDK2 , CDK4 , CDK7 , CDKN1A , CDKN1B , CKS1B , DHFR , E2F1 , MAX , MCM2 , MCM3 , MCM4 , MCM5 , MCM6 , MCM7 , MNAT1 , MYC , ORC1 , ORC2 , ORC4 , ORC5 , PCNA , POLA1 , POLE , POLE2 , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PRIM1 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTK6 , RB1 , RPA1 , RPA2 , RPA3 , RPS27A , RRM2 , SKP1 , SKP2 , TFDP1 , TFDP2 , TK2 , TYMS , UBA52 , UBB , UBC , WEE1 , SEM1 , CDC7 , CDC45 , CUL1 , CCNA1 , CCNE2 , PSMF1 , PSMD6 , AKT3 , PSME3 , PSMD14 , DBF4 , ORC6 , ORC3 , POLA2 , FBXO5 , PPP2R3B , RPA4 , POLE3 , MCM10 , POLE4 , CDT1 , MCM8 , C7orf76 , LOC100506136 ,