description
Cyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include proteins involved in the initiation of DNA replication. The two Cyclin E proteins are subjected to ubiquitin-dependent proteolysis, under the control of an E3 ubiquitin ligase known as the SCF. Cyclin A - Cdk2 complexes, which are also regulated by p21Cip1/Waf1 and p27kip1, are likely to be important for continued DNA synthesis, and progression into G2. An additional level of control of Cdk2 is reversible phosphorylation of Threonine-14 (T14) and Tyrosine-15 (Y15), catalyzed by the Wee1 and Myt1 kinases, and dephosphorylation by the three Cdc25 phosphatases, Cdc25A, B and C
external resources
NCBI:1269768
REACTOME:R-HSA-69206
genes
AKT1
,
AKT2
,
CCND1
,
CCNA2
,
CCNB1
,
CCNE1
,
CCNH
,
CDK1
,
CDC6
,
CDC25A
,
CDK2
,
CDK4
,
CDK7
,
CDKN1A
,
CDKN1B
,
CKS1B
,
DHFR
,
E2F1
,
MAX
,
MCM2
,
MCM3
,
MCM4
,
MCM5
,
MCM6
,
MCM7
,
MNAT1
,
MYC
,
ORC1
,
ORC2
,
ORC4
,
ORC5
,
PCNA
,
POLA1
,
POLE
,
POLE2
,
PPP2CA
,
PPP2CB
,
PPP2R1A
,
PPP2R1B
,
PRIM1
,
PSMA1
,
PSMA2
,
PSMA3
,
PSMA4
,
PSMA5
,
PSMA6
,
PSMA7
,
PSMB1
,
PSMB2
,
PSMB3
,
PSMB4
,
PSMB5
,
PSMB6
,
PSMB7
,
PSMB8
,
PSMB9
,
PSMB10
,
PSMC1
,
PSMC2
,
PSMC3
,
PSMC4
,
PSMC5
,
PSMC6
,
PSMD1
,
PSMD2
,
PSMD3
,
PSMD4
,
PSMD5
,
PSMD7
,
PSMD8
,
PSMD9
,
PSMD10
,
PSMD11
,
PSMD12
,
PSMD13
,
PSME1
,
PSME2
,
PTK6
,
RB1
,
RPA1
,
RPA2
,
RPA3
,
RPS27A
,
RRM2
,
SKP1
,
SKP2
,
TFDP1
,
TFDP2
,
TK2
,
TYMS
,
UBA52
,
UBB
,
UBC
,
WEE1
,
SEM1
,
CDC7
,
CDC45
,
CUL1
,
CCNA1
,
CCNE2
,
PSMF1
,
PSMD6
,
AKT3
,
PSME3
,
PSMD14
,
DBF4
,
ORC6
,
ORC3
,
POLA2
,
FBXO5
,
PPP2R3B
,
RPA4
,
POLE3
,
MCM10
,
POLE4
,
CDT1
,
MCM8
,
C7orf76
,
LOC100506136
,
