The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D:CDK complexes releases pRb from E2F, inducing E2F-targeted genes such as cyclin E

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CCNE1 , CDK1 , CDC6 , CDC25A , DHFR , E2F1 , ORC1 , PCNA , POLA1 , RRM2 , TFDP1 , TFDP2 , TK2 , TYMS , CDC45 , CCNA1 , FBXO5 , CDT1 ,