description
DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA (Frick & Richardson 2002; Wang et al 1984)
external resources
NCBI:1269780
REACTOME:R-HSA-68952
PUBMED:6693436
PUBMED:11395402
genes
POLA1
,
POLE
,
POLE2
,
PRIM1
,
POLA2
,
POLE3
,
POLE4
,
