description
Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap

external resources
NCBI:1269790
REACTOME:R-HSA-69166
PUBMED:7926735
PUBMED:8131753
PUBMED:7644470

genes
DNA2 , FEN1 , PCNA , POLA1 , POLD1 , POLD2 , PRIM1 , RPA1 , RPA2 , RPA3 , POLD3 , POLA2 , POLD4 ,