description
At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activity (Sagata 2005). Cyclin B1-bound Cdc2, which is the target of Cdc25C, Wee1A, and Myt1, functions in a feedback loop and phosphorylates the latter components (Cdc25C, Wee1A, Myt1). The Cdc2- dependent phosphorylation provides docking sites for the polo-box domain of Plk1, thus promoting the Plk1-dependent regulation of these components and, as a result, activation of Cdc2-Cyclin B1.PLK1 phosphorylates and activates the transcription factor FOXM1 which stimulates the expression of a number of genes needed for G2/M transition, including PLK1, thereby creating a positive feedback loop (Laoukili et al. 2005, Fu et al. 2008, Sadasivam et al. 2012, Chen et al. 2013)
external resources
NCBI:1269804
REACTOME:R-HSA-156711
PUBMED:15692562
PUBMED:22391450
PUBMED:15654331
PUBMED:15070733
PUBMED:23109430
PUBMED:19160488
genes
CCNB1
,
CDC25A
,
CDC25C
,
CENPF
,
EP300
,
FOXM1
,
MYBL2
,
PLK1
,
RBBP4
,
WEE1
,
PKMYT1
,
CCNB2
,
LIN37
,
LIN52
,
LIN54
,
LIN9
,
MIR1281
,
