description
At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activity (Sagata 2005). Cyclin B1-bound Cdc2, which is the target of Cdc25C, Wee1A, and Myt1, functions in a feedback loop and phosphorylates the latter components (Cdc25C, Wee1A, Myt1). The Cdc2- dependent phosphorylation provides docking sites for the polo-box domain of Plk1, thus promoting the Plk1-dependent regulation of these components and, as a result, activation of Cdc2-Cyclin B1.PLK1 phosphorylates and activates the transcription factor FOXM1 which stimulates the expression of a number of genes needed for G2/M transition, including PLK1, thereby creating a positive feedback loop (Laoukili et al. 2005, Fu et al. 2008, Sadasivam et al. 2012, Chen et al. 2013)

external resources
NCBI:1269804
REACTOME:R-HSA-156711
PUBMED:15692562
PUBMED:22391450
PUBMED:15654331
PUBMED:15070733
PUBMED:23109430
PUBMED:19160488

genes
CCNB1 , CDC25A , CDC25C , CENPF , EP300 , FOXM1 , MYBL2 , PLK1 , RBBP4 , WEE1 , PKMYT1 , CCNB2 , LIN37 , LIN52 , LIN54 , LIN9 , MIR1281 ,