description
Nuclear envelope breakdown in mitosis involves permeabilization of the nuclear envelope through disassembly of the nuclear pore complex (NPC) (reviewed by Guttinger et al. 2009). Nucleoporin NUP98, located at both the cytoplasmic and the nucleoplasmic side of the NPC (Griffis et al. 2003), and involved in the formation of the transport barrier through its FG (phenylalanine glycine) repeats that protrude into the central cavity of the NPC (Hulsmann et al. 2012), is probably the first nucleoporin that dissociates from the NPC at the start of mitotic NPC disassembly (Dultz et al. 2008). NUP98 dissociation is triggered by phosphorylation. Phosphorylation of NUP98 by CDK1 and NIMA family kinases NEK6 and/or NEK7 is needed for NUP98 dissociation from the NPC (Laurell et al. 2011). While the phosphorylation of NUP98 by CDK1 and NEK6/7 is likely to occur simultaneously, CDK1 and NEK6/7-mediated phosphorylations are shown as separate events, for clarity purposes

external resources
NCBI:1269817
REACTOME:R-HSA-3301854
PUBMED:18316408
PUBMED:21335236
PUBMED:12589057
PUBMED:19234477
PUBMED:22901806

genes
CCNB1 , CDK1 , NUP88 , NUP98 , RANBP2 , TPR , NUP214 , AAAS , RAE1 , CCNB2 , NUP155 , NUP93 , NUP58 , POM121 , NUP153 , NUP50 , NEK6 , NUPL2 , NUP205 , NUP210 , NUP160 , NUP188 , NUP62 , NUP54 , NDC1 , NUP133 , NUP107 , NUP37 , NUP85 , SEH1L , NEK9 , NUP35 , NEK7 , NUP43 , POM121C ,