description
The APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zachariae and Nasmyth, 1999). Cdc20, whose protein levels increase as cells enter into mitosis and decrease upon mitotic exit, only associates with the APC/C during M phase. Cdh1 associates with the APC/C in G1. This interaction is inhibited at other times by Cdk1 phosphorylation

external resources
NCBI:1269839
REACTOME:R-HSA-176408
PUBMED:16508672
PUBMED:12049731
PUBMED:12208841
PUBMED:15678131

genes
BUB1B , CCNA2 , CCNB1 , CDK1 , CDC20 , CDC27 , CDK2 , MAD2L1 , PLK1 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , SKP1 , UBA52 , UBB , UBC , UBE2D1 , UBE2E1 , SEM1 , CUL1 , CDC23 , CDC16 , CCNA1 , BTRC , BUB3 , PSMF1 , PSMD6 , PSME3 , PSMD14 , ANAPC10 , UBE2C , PSME4 , ANAPC15 , FBXO5 , ANAPC2 , ANAPC4 , FZR1 , ANAPC5 , ANAPC7 , ANAPC11 , ANAPC1 , ANAPC16 , PSMB11 , PSMA8 , CDC26 , C7orf76 , LOC100506136 ,